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Volume 6 Issue 1
Oct.  2023
Article Contents

Zhou Z Z, Liu C R, Guo Y T, Pang Y, Sun W. 2024. Engineering vascularized organotypic tissues via module assembly. Int. J. Extrem. Manuf. 6  012006.
Citation: Zhou Z Z, Liu C R, Guo Y T, Pang Y, Sun W. 2024. Engineering vascularized organotypic tissues via module assembly. Int. J. Extrem. Manuf.  012006.

Engineering vascularized organotypic tissues via module assembly


doi: 10.1088/2631-7990/acfcf2
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  • Publish Date: 2023-10-11
  • Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular maturation make vascularized organotypic tissue construction difficult, greatly limiting its use in tissue engineering and regenerative medicine. To address these limitations, recent studies have adopted pre-vascularized microtissue assembly for the rapid generation of functional tissue analogs with dense vascular networks and high cell density. In this article, we summarize the development of module assembly-based vascularized organotypic tissue construction and its application in tissue repair and regeneration, organ-scale tissue biomanufacturing, as well as advanced tissue modeling.

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Engineering vascularized organotypic tissues via module assembly

doi: 10.1088/2631-7990/acfcf2
  • 1 Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Haidian District, Beijing 100084, People's Republic of China;
  • 2 Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Beijing 100084, People's Republic of China;
  • 3 Key Laboratory for Advanced Materials Processing Technology, Ministry of Education, Beijing 100084, People's Republic of China;
  • 4 Department of Mechanical Engineering, Drexel University, Philadelphia, PA 19104, United States of America

Abstract: 

Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular maturation make vascularized organotypic tissue construction difficult, greatly limiting its use in tissue engineering and regenerative medicine. To address these limitations, recent studies have adopted pre-vascularized microtissue assembly for the rapid generation of functional tissue analogs with dense vascular networks and high cell density. In this article, we summarize the development of module assembly-based vascularized organotypic tissue construction and its application in tissue repair and regeneration, organ-scale tissue biomanufacturing, as well as advanced tissue modeling.

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