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Volume 5 Issue 3
May  2023
Article Contents

Wang Y X, Pereira R F, Peach C, Huang B Y, Vyas C, Bartolo P. 2023. Robotic in situ bioprinting for cartilage tissue engineering. Int. J. Extrem. Manuf. 5 032004.
Citation: Wang Y X, Pereira R F, Peach C, Huang B Y, Vyas C, Bartolo P. 2023. Robotic in situ bioprinting for cartilage tissue engineering. Int. J. Extrem. Manuf. 032004.

Robotic in situ bioprinting for cartilage tissue engineering


doi: 10.1088/2631-7990/acda67
More Information
  • Publish Date: 2023-05-18
  • Articular cartilage damage caused by trauma or degenerative pathologies such as osteoarthritis can result in significant pain, mobility issues, and disability. Current surgical treatments have a limited capacity for efficacious cartilage repair, and long-term patient outcomes are not satisfying. Three-dimensional bioprinting has been used to fabricate biochemical and biophysical environments that aim to recapitulate the native microenvironment and promote tissue regeneration. However, conventional in vitro bioprinting has limitations due to the challenges associated with the fabrication and implantation of bioprinted constructs and their integration with the native cartilage tissue. In situ bioprinting is a novel strategy to directly deliver bioinks to the desired anatomical site and has the potential to overcome major shortcomings associated with conventional bioprinting. In this review, we focus on the new frontier of robotic-assisted in situ bioprinting surgical systems for cartilage regeneration. We outline existing clinical approaches and the utilization of robotic-assisted surgical systems. Handheld and robotic-assisted in situ bioprinting techniques including minimally invasive and non-invasive approaches are defined and presented. Finally, we discuss the challenges and potential future perspectives of in situ bioprinting for cartilage applications.

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Robotic in situ bioprinting for cartilage tissue engineering

doi: 10.1088/2631-7990/acda67
  • 1 Department of Mechanical, Aerospace and Civil Engineering, University of Manchester, Manchester M13 9PL, United Kingdom;
  • 2 Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal;
  • 3 Instituto de Investigação e Inovação em Sáude, Universidade do Porto, 4200-135 Porto, Portugal;
  • 4 Instituto de Engenharia Biomédica, Universidade do Porto, 4200-135 Porto, Portugal;
  • 5 Manchester University NHS Foundation Trust, Manchester, United Kingdom;
  • 6 Singapore Centre for 3D Printing, School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore

Abstract: 

Articular cartilage damage caused by trauma or degenerative pathologies such as osteoarthritis can result in significant pain, mobility issues, and disability. Current surgical treatments have a limited capacity for efficacious cartilage repair, and long-term patient outcomes are not satisfying. Three-dimensional bioprinting has been used to fabricate biochemical and biophysical environments that aim to recapitulate the native microenvironment and promote tissue regeneration. However, conventional in vitro bioprinting has limitations due to the challenges associated with the fabrication and implantation of bioprinted constructs and their integration with the native cartilage tissue. In situ bioprinting is a novel strategy to directly deliver bioinks to the desired anatomical site and has the potential to overcome major shortcomings associated with conventional bioprinting. In this review, we focus on the new frontier of robotic-assisted in situ bioprinting surgical systems for cartilage regeneration. We outline existing clinical approaches and the utilization of robotic-assisted surgical systems. Handheld and robotic-assisted in situ bioprinting techniques including minimally invasive and non-invasive approaches are defined and presented. Finally, we discuss the challenges and potential future perspectives of in situ bioprinting for cartilage applications.

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